Revpenum

Composition: Meropenem

Strengths: 1000mg/1gm

Dosage From: Powder for reconstitution for injection or infusion.

Pharmacodynamics: Meropenem is a board-spectrum carbapenem antibiotic. The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin binding-protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus.
Meropenem is bactericidal except against Listeria monocytogenes, where it is bacteriostatic.

Pharmacokinetics:

Cmax: 61.6mcg/ml
• Half-life: 0.98 hours
• Volume of distribution (Vd): 12.5L

Indications:

• 1. Intra-abdominal infections
• 2. Bacterial Meningitis
• 3. Complicated Skin and Skin structure infections
• 4. Empirical therapy in serious infections

Dosage:

• For Adults: Intra-abdominal infections: 1gm IV every 8 hours.
  Meningitis, bacterial: 2gm IV every 8 hourly.

Contraindications: Contraindicated in patients with known hypersensitivity to this drug.

Warnings and Precautions:

• Renal Impairment: Dosage should be reduced in patients with creatinine clearance of 50 ml / min or less.
• Hepatic Impairment: No evidence that the dose has to be reduced in patients with hepatic impairment.
• Pregnancy: Category ‘B’.
• Lactation: Unknown whether drug is excreted in breast milk; use with caution.